网站地图 | 联系我们  
首页 中心概况 新闻动态 科研进展 交流合作 人才培养 研究队伍 人才招聘 政策规章 数学交叉科学传播
学术报告
现在位置:首页 > 学术报告

Kinetic Monte Carlo Simulations of Multicellular Aggregate Self-Assembly in Biofabrication
【2014.6.19 4:00pm, Z311】

【打印】【关闭】

 2014-6-20 

  Colloquia & Seminars 

  Speaker

Assistant Prof. Yi Sun,University of South Carolina  

  Title

Kinetic Monte Carlo Simulations of Multicellular Aggregate Self-Assembly in Biofabrication                     

  Time

2014.6.19 4:00pm                                                         

  Venue

Z311

  Abstract

We present a three-dimensional lattice model to study self-assembly and fusion of multicellular aggregate systems by using kinetic Monte Carlo (KMC) simulations. This model is developed to describe and predict the time evolution of postprinting morphological structure formation during tissue or organ maturation in a novel biofabrication process (or technology) known as bioprinting. In this new technology, live multicellular aggregates as bio-ink are used to make tissue or organ constructs via the layer-by-layer deposition technique in biocompatible hydrogels; the printed bio-constructs embedded in the hydrogels are then placed in bioreactors to undergo the self-assembly process to form the desired functional tissue or organ products. Here we implement our model with an efficient KMC algorithm to simulate the making of a set of tissues/organs in several designer's geometries like a ring, a sheet and a tube, which can involve a large number of cells and various other support materials like agarose constructs etc. We also study the process of cell sorting/migration within the cellular aggregates formed by multiple types of cells with different adhesivities.

  Affiliation

 

欢迎访问国家数学与交叉科学中心 
地址:北京海淀区中关村东路55号 邮编:100190 电话: 86-10-62613242 Fax: 86-10-62616840 邮箱: ncmis@amss.ac.cn